Depression is a very real condition that affects 1 in 10 Americans. Though some dealing with depression at various stages are able to treat and cure their symptoms using an Anti-Depressant medication and/or psychiatry, others are not as successful and end up dealing with Treatment-Resistant Depression (TRD). TRD occurs as a result of major depressive disorder which has occurred due to an unsuccessful attempt at treating depression through regular dosages of anti-depressant medication. A variation and/or combination of anti-depressants can be prescribed in this case to help counteract different symptoms in an attempt to treat the depression. Unfortunately, even these drastic measures can still show little to no success, leaving affected individuals feeling hopeless, defeated and even more anxious about their condition. The reality of the TRD can be quite hash, as those affect feel like there are no other options. In fact, one study suggests that anywhere from 29 to 46% of people (depending on the type of medication) fail to respond to treatment of an anti-depressant and 15% of these patients find no relief in multiple treatment trials.